Donovanosis With Bowen Disease.

A 45-year-old farmer presented with ulcers and plaques over his scrotum for the past 4 to 5 years. The condition started as a small lesion on the shaft of the penis, which improved with treatment; however, after 2 to 3 months, papulonodular lesions developed on the scrotum, which increased in size and subsequently broke down to form ulcers. He denied drug abuse but had a history of multiple unprotected sexual exposures. He was prescribed oral antibiotics, which improved the lesions, but he failed to take the antibiotics for more than a week. He also used powders, lotions, and salves (exact nature not known), which did not help and sometimes even burned the skin. After stopping the medicine, he developed new lesions that followed a similar course. Examination revealed nontender ulcers on the scrotum with raised, rolled-out margins and pale red, granulation tissue that bled on touch (Figure 1). In addition, there were nodules with a pinkish red granular surface and scaly erythematous plaques on the scrotum. Regional lymph nodes were not enlarged.

Tumor fibrohistiocítico plexiforme con metástasis ganglionar: reporte de un caso / Plexiform fibrohistiocytic tumor with nodal metastasis: a case report

El tumor fibrohistiocítico plexiforme (TFHP) es una rara neoplasia mesenquimal de malignidad intermedia, con alta tasa de recidiva local y potencial metastásico ganglionar o pulmonar. Suele afectar tejidos blandos superficiales de extremidades superiores de niños y adultos jóvenes, con predilección femenina. Presentamos el caso de un niño de 10 años con tumoración de crecimiento progresivo, dependiente del plano cutáneo en rodilla derecha con adenopatías inguinales ipsilaterales. Se le realiza resección amplia de la lesión con linfadenectomía inguinocrural. El estudio histopatológico reveló una neoplasia de patrón plexiforme con componente bifásico (células mononucleares tipo histiocitos asociado a células gigantes tipo osteoclasto, CD68 positivas y células fusiformes, actina de músculo liso positivas); favoreciendo el diagnóstico de esta entidad con metástasis ganglionar (AU)

Plexiform fibrohistiocytic tumour (TFHP) is a rare mesenchymal neoplasm of intermediate malignancy but with a high rate of local recurrence and potential for lymph node or pulmonary metastases. It usually affects superficial soft tissues of the upper extremities of children and young adults and is more frequent in females. We report a case of a 10 year old boy with progressive tumour growth, under the skin in the right knee with ipsilateral inguinal lymphadenopathy. He underwent wide resection of the lesion with inguinal lymphadenectomy. Histopathology revealed a plexiform pattern with a biphasic component (mononuclear histiocytic cells associated with CD68 positive osteoclast-like giant cells and smooth muscle actin-positive spindle cells); favoring the diagnosis of TFHP with lymph node metastasis (AU)

Sexually Transmitted Infections.

Sexually transmitted infections (STIs) remain a significant burden on public health in the United States. Primary prevention counseling with early diagnosis and treatment remain the best methods to decrease the incidence of STIs. Through significant public heath interventions, the incidence of gonorrhea, Chlamydia, and trichomoniasis is decreasing; however, the incidence of primary and secondary syphilis is increasing. Human papilloma virus remains the most common STI, but new vaccinations have the possibility of having a significant impact on this virus's disease potential. This review discusses the most common STIs in the United States, focusing on clinical presentation, diagnosis, and treatment.

Squamous cell carcinoma complicating donovanosis not a thing of the past!

Donovanosis causes granulomatous ulceration of genitalia and neighbouring sites with little tendency to heal spontaneously. It is uncommonly seen nowadays in sexually transmitted infection clinics of north India. The present case is reported for its scarcity and to make clinicians aware of this disease which may rarely accompany carcinoma.

Enfermedades de transmisión sexual. Manifestaciones orales / Sexually transmitted diseases. Oral manifestations. Update

Las enfermedades de transmisión sexual (ETS) son enfermedades infecto-contagiosas producidas por microrganismos patógenos que se transmiten, principalmente, durante las relaciones sexuales y que infectan las áreas genitales u otras zonas del cuerpo humano. Su origen son microrganismos patógenos: bacterias, protozoos, virus, hongos y ectoparásitos. En ocasiones estas enfermedades producen manifestaciones en el territorio orofacial que es necesario conocer e identificar (AU)

Sexually transmitted diseases (STD) are infectious-contagious diseases produced by pathogenic microorganisms that are transmitted, principally, during sexual relations and that infect the genital areas or other zones of the human body. They have their origin in pathogenic microorganisms: bacteria, protozoa, viruses, fungi and ectoparasites. On occasions these diseases produce manifestations in the orofacial area which is necessary to know or identify (AU)

Genital elephantiasis due to donovanosis: forgotten but not gone yet ...

Genital elephantiasis is a disease that is characterized by massive enlargement of the genitalia. Early aetiological diagnosis is of paramount importance so that development of genital elephantiasis can be prevented; otherwise it is not completely reversible with medical therapy and often requires surgical intervention. Chronic mental distress and disability can result as it interferes with daily/routine activities of the affected individual. Over time, the infectious causes of genital elephantiasis have evolved, from syphilis in the pre-penicillin era to donovanosis, lymphogranuloma venereum and recently filariasis, tuberculosis, leishmaniasis, HIV and chromoblastomycosis. With a declining prevalence globally, donovanosis is at risk of being forgotten as a cause of genital swelling; however, it is known to persist for years without treatment and can lead to complications such as lymphoedema and genital mutilation. We herein present a case of genital elephantiasis that was eventually diagnosed as being due to donovanosis.

Vulvar edema.

Vulvar edema is associated with a variety of conditions. The edema can result from inflammatory conditions, infections, infestations, trauma, pregnancy, tumors and iatrogenic causes. At times, it is difficult to determine the cause of the vulvar edema. Treatment consists of determining the origin of the edema and giving the appropriate therapy for that diagnosis as well as the use of compression and, at times, lymphatic massage.

Donovanosis genital / Genital donovanosis

Presentamos un caso de donovanosis genital en una gestante cuyo diagnóstico fue dificultoso dada la baja incidencia de esta enfermedad en nuestro país. La donovanosis o granuloma inguinal es una infección de transmisión sexual, causa de úlcera genital crónica no dolorosa. Es una enfermedad endémica en países tropicales y subtropicales. Debido al aumento de la inmigración procedente de estas zonas y al turismo sexual a países endémicos, estamos asistiendo a un aumento de esta patología infecciosa poco prevalente hasta ahora en nuestro medio (AU)

We report a case of genital donovanosis in a pregnant woman, whose diagnosis was difficult because of the low incidence of this disease in our country. Donovanosis or granuloma inguinale is a sexually transmitted infection that causes chronic genital painless ulceration. It is an endemic disease in tropical and subtropical countries. Due to the increase of immigration coming from these countries and sexual tourism in endemic countries, we are witnessing an increase in this infectious disease not very prevalent in our country until now (AU)

Plasminogen deficiency as a rare cause of conjunctivitis and lymphadenopathy.

Plasminogen deficiency is a rare disorder complicated by the subsequent formation of firm "woody" plaques in the eye (ligneous conjunctivitis) or other mucosal sites as the result of inflammation or trauma. The plaques are composed of fibrinogen, granulation tissue, and inflammatory cells. The findings may be considered nonspecific by the unsuspecting surgical pathologist and delay the appropriate diagnosis. We report the first case of lymph node involvement with characteristic eosinophilic hyaline deposits that are periodic acid Schiff positive, stain dark red with Masson trichrome, and contain fibrinogen as detected by immunofluorescence and describe the longitudinal evolution of this patient's disease over a 15-year period. The differential diagnosis of amorphous hyaline material in lymph node biopsies is discussed.

Malignant transformation of donovanosis (granuloma inguinale) in a HIV-positive patient.

Donovanosis is endemic in various parts of the world. Although donovanosis has been reported to co-exist with the human immunodeficiency virus (HIV) infection, to our knowledge there have been no reports of co-existent squamous cell carcinoma (SCC) in an HIV positive patient. In our case the patient did not respond to treatment for donovanosis and on biopsy we realized that the patient had coexistent SCC, which is hitherto unreported with granuloma inguinale.

Donovanosis with auto-amputation of penis in a HIV-2 infected person.

Donovanosis is a slowly progressive, granulomatous ulcerative disease , caused by Klebsiella (Calymmatobacterium) granulomatis. The disease is known to persist for years together, leading to complications. A male patient aged 30 years with underlying HIV-2 infection presented to the department of STD with painful ulceration over the genital region of 5 months duration, with absence of penis. Tissue smear from the ulcer and histopathological examination revealed large histiocytes with intracellular Donovan bodies (Pund cell). A final diagnosis of donovanosis with auto-amputation of penis with HIV-2 infection was made. The old conventional medicines, viz. streptomycin, doxycycline and amoxycillin, were effective. Though HIV-2 infections are milder than HIV-1 infections in all aspects, donovanosis in this HIV-2 infected case presented with complications. However, since the CD4 count was 748 cells/cmm, the severity is attributed to the long standing nature and negligence by the patient, and not to possible immunodeficiency.

Donovanosis: [review]

Donovanosis is a chronic bacterial illness frequently associated with sexually transmitted infections (STI) and is under diagnosed both in endemic areas as well as in countries in which doctors have little experience with tropical diseases. The utilization of syndromic diagnosis and treatment of STIs in various parts of the world and the previous use of antibiotics make it difficult to find Donovan bodies in the cytodiagnostic and hystopathological exams, requiring the utilization of technology that is neither routine nor often accessible to confirm the hypothesized diagnosis. Therefore, it is necessary to bring medical professionals up to date about this infectious disease.

Donovanosis.

Donovanosis is a chronic bacterial illness frequently associated with sexually transmitted infections (STI) and is under diagnosed both in endemic areas as well as in countries in which doctors have little experience with tropical diseases. The utilization of syndromic diagnosis and treatment of STIs in various parts of the world and the previous use of antibiotics make it difficult to find Donovan bodies in the cytodiagnostic and hystopathological exams, requiring the utilization of technology that is neither routine nor often accessible to confirm the hypothesized diagnosis. Therefore, it is necessary to bring medical professionals up to date about this infectious disease.

[Genital ulcers caused by sexually transmitted diseases: current therapies, diagnosis and their relevance in HIV pandemy]. / Ulceras genitais causadas por infecções sexualmente transmissíveis: actualização do diagnóstico e terapêuticas, e a sua importância na pandemia do VIH.

The sexual transmitted pathogens associated with genital ulcers are Treponema pallidum, Haemophilus ducreyi, Calymmatobacterium granulomatis, Chlamydia trachomatis and Herpes simplex virus type 1 or 2. Although geographic differences still exist, herpetic infections prevalence is growing worldwide as the most frequent ulcerative sexual transmitted disease. The failure of the many different used guidelines in achieving a sustained reduction in the number of new cases, in particular the WHO syndromic management, leads into an over treatment of bacterial agents and missing of viral agents. This situation is also associated with poor efficacy and wasting of economical resources. Ulcerative and non-ulcerative sexual transmitted diseases are important in the world HIV pandemy because they promote HIV transmission and are also associated with the disease evolution. Portugal had until recently the highest incidence of HIV infection in Europe and that points out to importance of treating and control of both ulcerative and non-ulcerative sexual transmitted diseases in order.

Bilateral psoas abscess in a case of granuloma inguinale / Absceso bilateral de psoas en un caso de granuloma inguinal

The authors present a case of disseminated granuloma inguinale with bilateral psoas abscesses. Infection with calymmatobacterium granulomatis is usually localized to the genital organs but rarely may be disseminated. A search of the literature revealed that only two cases of psoas abscesses due to calymmatobacterium granulomatis were previously reported.

Los autores presentan un caso de granuloma inguinal diseminado con abscesos bilaterales de psoas. La infección con calymmatobacterium granulomatis normalmente se localiza en los órganos genitales, y raramente se disemina. La literatura reveló sólo dos casos de abscesos de psoas debidos a calymmatobacterium granulomatis reportados con anterioridad.

Escrofuloderma de larga evolución / Long-standing scrofuloderma

Presentamos el caso de una mujer ecuatoriana de 26 años que presentaba múltiples cicatrices hipertróficas a lo largo del miembro inferior izquierdo secundarias a un proceso cutáneo que sufría desde hacía 11 años, previamente diagnosticado y tratado en su país como una leishmaniasis cutánea. Presentaba empeoramiento clínico desde hacía 9 meses con supuración a través de las cicatrices de la ingle y del muslo, asociado a dolor local y síntomas sistémicos. Partiendo de la sospecha de tuberculosis cutánea le practicamos numerosas exploraciones complementarias para confirmar el diagnóstico y descartar la afectación ósea. Finalmente, el cultivo de una biopsia ganglionar confirmó que se trataba de un escrofuloderma

We present the case of a 26-year-old Ecuadorian woman who presented with multiple hypertrophic scars along the lower left limb, secondary to a cutaneous process that she had had for 11 years, previously diagnosed and treated in her country as cutaneous leishmaniasis. It had been clinically worsening for 9 months with suppuration through the scars in the groin and thigh, associated with local pain and systemic symptoms. As we suspected cutaneous tuberculosis, we performed a number of complementary examinations to confirm the diagnosis and rule out bone involvement. Finally, a lymph node culture confirmed that it was scrofuloderma